If you have a confirmed diagnosis of a fungal toenail, consistent topical antifungal treatment can prove effective in some cases. For tougher fungal nails that area more involved or do not respond to topical therapies, oral therapy is also an option. In some instances the affected nail/nails can be removed. This can be done permanently if you have exhausted all other option or can be done temporarily to treat the nail bed in hopes of a healthy nail growing back in.